Lattice Models of RNA-DNA R-loop Complexes
Date
2023
Authors
Numedahl, Olivia
Schmirler, Matthew
Ferrari, Margherita Maria
Soteros, Chris
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Poster Presentation
Degree Level
Abstract
Two models are combined to explore the formation and stability of DNA-RNA structures called
R-loops. The first is a formal grammar model (FGM) developed by Ferrari and coworkers. The
second is a simplified lattice model developed for studying R-loop formation and geometry by
Soteros and coworkers for a PIMS VXML project. We combine these into one model and explore
the model both theoretically and via computer simulation using Markov chains. The general
goals are to explore the probability of R-loop formation and geometric properties of the R-loops.
Description
Keywords
RNA, DNA, R-loop formation, Lattice models