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Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife

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dc.contributor.authorBerg, Martin Van den
dc.contributor.authorBirnbaum, Linda
dc.contributor.authorBosveld, Albertus T.C.
dc.contributor.authorBrunstrom, Björn
dc.contributor.authorCook, Philip
dc.contributor.authorFeely, Mark
dc.contributor.authorGiesy, John
dc.contributor.authorHanberg, Annika
dc.contributor.authorHasegawa, Ryuichi
dc.contributor.authorKennedy, Sean W.
dc.contributor.authorKubiak, Timothy
dc.contributor.authorLarsen, John Christian
dc.contributor.authorLeeuwen, F.X. Rolaf van
dc.contributor.authorLiem, A.K. Djien
dc.contributor.authorNolt, Cynthia
dc.contributor.authorPeterson, Richard E.
dc.contributor.authorPoellinger, Lorenz
dc.contributor.authorSafe, Stephen
dc.contributor.authorSchrenk, Dieter
dc.contributor.authorTillitt, Donald
dc.contributor.authorTysklind, Mats
dc.contributor.authorYounes, Maged
dc.contributor.authorWaern, Fredrik
dc.contributor.authorZacharewski, Tim
dc.date.accessioned2023-08-26T06:38:46Z
dc.date.available2023-08-26T06:38:46Z
dc.date.issued1998
dc.descriptionReproduced with permission from Environmental Health Perspectives EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.en_US
dc.description.abstractAn expert meeting was organized by the World Health Organization (WHO) and held in Stockholm on 15-18 June 1997. The objective of this meeting was to derive consensus toxic equivalency factors (TEFs) for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and dioxinlike polychlorinated biphenyls (PCBs) for both human, fish, and wildlife risk assessment. Based on existing literature data, TEFs were (re)evaluated and either revised (mammals) or established (fish and birds). A few mammalian WHO-TEFs were revised, including 1,2,3,7,8-pentachlorinated DD, octachlorinated DD, octachlorinated DF, and PCB 77. These mammalian TEFs are also considered applicable for humans and wild mammalian species. Furthermore, it was concluded that there was insufficient in vivo evidence to continue the use of TEFs for some di-ortho PCBs, as suggested earlier by Ahlborg et al. [Chemosphere 28:1049-1067 (1994)]. In addition, TEFs for fish and birds were determined. The WHO working group attempted to harmonize TEFs across different taxa to the extent possible. However, total synchronization of TEFs was not feasible, as there were orders of a magnitude difference in TEFs between taxa for some compounds. In this respect, the absent or very low response of fish to mono-ortho PCBs is most noticeable compared to mammals and birds. Uncertainties that could compromise the TEF concept were also reviewed, including nonadditive interactions, differences in shape of the dose-response curve, and species responsiveness. In spite of these uncertainties, it was concluded that the TEF concept is still the most plausible and feasible approach for risk assessment of halogenated aromatic hydrocarbons with dioxinlike properties.en_US
dc.description.versionPeer Revieweden_US
dc.identifier.citationM Van den Berg, L Birnbaum, A T Bosveld, B Brunström, P Cook, M Feeley, J P Giesy, A Hanberg, R Hasegawa, S W Kennedy, T Kubiak, J C Larsen, F X van Leeuwen, A K Liem, C Nolt, R E Peterson, L Poellinger, S Safe, D Schrenk, D Tillitt, M Tysklind, M Younes, F Waern, and T Zacharewski (1998). Environmental Health Perspectives. Vol. 106, No. 12. https://doi.org/10.1289/ehp.98106775en_US
dc.identifier.doi10.1289/ehp.98106775
dc.identifier.urihttps://hdl.handle.net/10388/14930
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciences (NIEHS)en_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjecttoxic equivalency factors (TEFs)en_US
dc.subjectrisk assessmenten_US
dc.subjectmammalian TEFsen_US
dc.subjectWHO 1997en_US
dc.titleToxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlifeen_US
dc.typeArticleen_US

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