Biomedical Sciences
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Biomedical Sciences is composed of two basic science departments: Anatomy, Physiology and Pharmacology; and Biochemistry, Microbiology and Immunology.
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Item Synaptic plasticity in learning and memory: stress effects in the hippocampus(Elsevier, 2008) Wang, Yu Tian; Howland, JohnItem Ventral hippocampal involvement in temporal order, but not recognition, memory for spatial information(Wiley, 2008) Howland, John; Harrison, Rebecca; Hannesson, Darren; Phillips, AnthonyItem Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring(Elsevier, 2015) Chandna, Andrew; Kuhlmann, Naila; Bryce, Courtney; Greba, Quentin; Campanucci, Veronica; Howland, John GItem The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats(Elsevier, 2016) Marks, Wendie; Greba, Quentin; Cain, Stuart; Snutch, Terrance; Howland, John G.Item The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg(Elsevier, 2016) Marks, Wendie; Cain, Stuart; Snutch, Terrance; Howland, John G.Item The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans(Wiley, 2016) Marks, Wendie; Cavanagh, Mary; Greba, Quentin; Cain, Stuart; Snutch, Terrance; Howland, John G.Item Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers(Elsevier, 2016) Lins, Brittney; Howland, John G.Item Effects of stress on behavioral flexibility in rodents(Elsevier, 2017) Hurtubise, Jessica; Howland, JohnItem Dissociable effects of the d- and l- enantiomers of govadine on the disruption of prepulse inhibition by MK-801 and apomorphine in male Long-Evans rats(2017) Lins, Brittney; Marks, Wendie; Phillips, Anthony; Howland, JohnItem Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: Reversal by the T-type calcium channel antagonist Z944(Elsevier, 2017) Henbid, Mark; Marks, Wendie; Collins, Madeline; Cain, Stuart; Snutch, Terrance; Howland, John G.Item Maternal immune activation during pregnancy in rats impairs working memory capacity of the offspring(Elsevier, 2017) Murray, Brendan; Davies, Don; Molder, Joel; Howland, John G.Item Performance of the odour span task is not impaired following inactivations of parietal cortex in rats(2018) Scott, Gavin; Zabder, Nadine; Greba, Quentin; Howland, JohnItem Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers(Elsevier, 2018) Roebuck, Andrew; Liu, Max; Lins, Brittney; Scott, Gavin; Howland, John G.Item The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg(Elsevier, 2019) Marks, Wendie; Zabder, Nadine; Cain, Stuart; Snutch, Terrance; Howland, John G.Item Performance of the trial-unique, delayed non-matching-to-location (TUNL) task depends on AMPA/Kainate, but not NMDA, ionotropic glutamate receptors in the rat posterior parietal cortex(Elsevier, 2019) Scott, Gavin; Roebuck, Andrew; Greba, Quentin; Howland, John G.Item The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg(2019) Marks, Wendie; Zabder, Nadine; Cain, Stuart; Snutch, Terrance; Howland, JohnItem Evidence for altered insulin signaling in the brains of Genetic Absence Epilepsy Rats from Strasbourg(2020) Sekar, Sathiya; Marks, Wendie; Gopalakrishnan, Venkat; Greba, Quentin; Snutch, Terrance; Howland, John; Taghibiglou, ChangizItem NMDA receptors in visual and olfactory sensory integration in male Long Evans rats: a role for the orbitofrontal cortex(2020) Sandini, Thaisa; Marks, Wendie; Tahir, Nimra; Song, Yen; Greba, Quentin; Howland, JohnItem T-type calcium channels regulate the acquisition and recall of conditioned fear in male, Wistar rats(2020) Marks, Wendie; Zabder, Nadine; Snutch, Terrance; Howland, JohnItem Evolutionary repression of chondrogenic genes in the vertebrate osteoblast(Wiley, 2020-01-28) Nguyen, Jason; eames, brianGene expression in extant animals might reveal how skeletal cells have evolved over the past 500 million years. The cells that make up cartilage (chondrocytes) and bone (osteoblasts) express many of the same genes, but they also have important molecular differences that allow us to distinguish them as separate cell types. For example, traditional studies of later-diverged vertebrates, such as mouse and chick, defined the genes Col2a1 and sex-determining region Y-box 9 as cartilage-specific. However, recent studies have shown that osteoblasts of earlier-diverged vertebrates, such as frog, gar, and zebrafish, express these 'chondrogenic' markers. In this review, we examine the resulting hypothesis that chondrogenic gene expression became repressed in osteoblasts over evolutionary time. The amphibian is an underexplored skeletal model that is uniquely positioned to address this hypothesis, especially given that it diverged when life transitioned from water to land. Given the relationship between phylogeny and ontogeny, a novel discovery for skeletal cell evolution might bolster our understanding of skeletal cell development.