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THE EFFECTS OF INTERMITTENT FASTING AND A HIGH PROTEIN DIET IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS

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dc.contributor.advisorArnason, Terraen_US
dc.contributor.advisorMansell, Kerryen_US
dc.contributor.committeeMemberShoker, Ahmeden_US
dc.contributor.committeeMemberDavis, Karenen_US
dc.contributor.committeeMemberArnold, Barten_US
dc.contributor.committeeMemberChizen, Donnaen_US
dc.creatorBowen, Matthewen_US
dc.date.accessioned2015-09-18T12:00:18Z
dc.date.available2015-09-18T12:00:18Z
dc.date.created2015-09en_US
dc.date.issued2015-09-17en_US
dc.date.submittedSeptember 2015en_US
dc.description.abstractIntermittent fasting (IF) is a recently popularized meal timing strategy whereby individuals abstain continuously from any energy intake for 16 to 20 hours each day, subsequently condensing energy intake into a short period spanning 4 to 8 hours. We aimed to test the effects of intermittent fasting in 10 individuals with Type 2 Diabetes Mellitus in conjunction with recommendations to consume a high protein diet in a 6 to 8 week withdrawal study. This study consisted of three phases: baseline, intervention, and follow-up. During the 2-week baseline and intervention phases participants consumed meals at regular times. Biochemical, anthropometric, and physical activity measurements were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose and fasting duration on a daily basis, in addition to completing a remote food photography diary three times within each study phase. Despite the short duration of the intervention phase, intermittent fasting led to significant decreases in weight, BMI, morning SMBG, and overall reductions in waist circumference, C-reactive protein, energy intake, carbohydrate intake, and fat intake. There were significant variations between participants in response to intermittent fasting in respect to changes in lipids and insulin sensitivity, which could not be explained by baseline biochemical or anthropometric measures, fasting duration, energy intake, or physical activity. Upon cessation of intermittent fasting, biochemical changes regressed towards baseline values during the follow-up period. Intermittent fasting was well tolerated by most participants, and no severe adverse events were noted. Morning nausea was the most common complaint, which abruptly ceased when medication timing was changed.en_US
dc.identifier.urihttp://hdl.handle.net/10388/ETD-2015-09-2226en_US
dc.language.isoengen_US
dc.subjectIntermittent Fastingen_US
dc.subjectType 2 Diabetesen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectDiabetes Mellitus Type 2en_US
dc.subjectNon Insulin Dependent Diabetes Mellitusen_US
dc.subjectNIDDMen_US
dc.subjectIFen_US
dc.subjectHigh Protein Dieten_US
dc.subjectMeal Frequencyen_US
dc.subjectSelf-Monitored Blood Glucoseen_US
dc.subjectFastingen_US
dc.subjectFasten_US
dc.titleTHE EFFECTS OF INTERMITTENT FASTING AND A HIGH PROTEIN DIET IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUSen_US
dc.type.genreThesisen_US
dc.type.materialtexten_US
thesis.degree.departmentPharmacy and Nutritionen_US
thesis.degree.disciplinePharmacyen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (M.Sc.)en_US

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