Effect of prolonged stimulation of the heme oxygenase/carbon monoxide system by hemin on blood pressure and penile erection of spontaneously hypertensive rats
| dc.contributor.advisor | Wang, Rui | en_US |
| dc.contributor.committeeMember | West, Nigel | en_US |
| dc.contributor.committeeMember | Sulakhe, Prakash | en_US |
| dc.contributor.committeeMember | Gopalakrishnan, Venkat | en_US |
| dc.contributor.committeeMember | Fisher, Thomas E. | en_US |
| dc.contributor.committeeMember | Desautels, Michel | en_US |
| dc.creator | Shamloul, Rany Mohamed | en_US |
| dc.date.accessioned | 2006-11-29T14:34:45Z | en_US |
| dc.date.accessioned | 2013-01-04T05:09:18Z | |
| dc.date.available | 2006-11-30T08:00:00Z | en_US |
| dc.date.available | 2013-01-04T05:09:18Z | |
| dc.date.created | 2006-11 | en_US |
| dc.date.issued | 2006-11-30 | en_US |
| dc.date.submitted | November 2006 | en_US |
| dc.description.abstract | Essential hypertension (EH) is a risk factor for many cardiovascular disorders. Treatment of established EH, especially for prolonged control of this pathogenic process, represents a great challenge. Moreover, hypertension is considered an important risk factor for the development of many other diseases, e.g. erectile dysfunction. Hemin and other heme derivatives, e.g. heme-L-lysinate (HLL) and heme-L-arginate, have been used extensively to upregulate expression of heme oxygenase (HO) and production of endogenous carbon monoxide (CO). Short-term hemin administration for 4-5 days has been shown to markedly decrease high blood pressure (BP) in spontaneously hypertensive rats (SHR), but not in normotensive Wistar-Kyoto (WKY) or Sprague Dawley (SD) rats. This short-term therapy was effective in treating young, but not adult SHR. In the present study, hemin (15 mg/kg/day) was administered to 12-week old adult SHR through subcutaneously implanted osmotic minipumps for 3 consecutive weeks (the hemin protocol). Into the second week of the hemin protocol, BP of SHR was normalized from 203.2 ± 2.5 to 123.4 ±1.9 mmHg (n=20, p | en_US |
| dc.identifier.uri | http://hdl.handle.net/10388/etd-11292006-143445 | en_US |
| dc.language.iso | en_US | en_US |
| dc.subject | penile erection | en_US |
| dc.subject | heme oxygenase | en_US |
| dc.subject | hypertension | en_US |
| dc.title | Effect of prolonged stimulation of the heme oxygenase/carbon monoxide system by hemin on blood pressure and penile erection of spontaneously hypertensive rats | en_US |
| dc.type.genre | Thesis | en_US |
| dc.type.material | text | en_US |
| thesis.degree.department | Physiology | en_US |
| thesis.degree.discipline | Physiology | en_US |
| thesis.degree.grantor | University of Saskatchewan | en_US |
| thesis.degree.level | Doctoral | en_US |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) | en_US |