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      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
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      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
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      THE EFFECTS OF INTERMITTENT FASTING AND A HIGH PROTEIN DIET IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS

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      BOWEN-THESIS.pdf (1.767Mb)
      Date
      2015-09-17
      Author
      Bowen, Matthew
      Type
      Thesis
      Degree Level
      Masters
      Metadata
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      Abstract
      Intermittent fasting (IF) is a recently popularized meal timing strategy whereby individuals abstain continuously from any energy intake for 16 to 20 hours each day, subsequently condensing energy intake into a short period spanning 4 to 8 hours. We aimed to test the effects of intermittent fasting in 10 individuals with Type 2 Diabetes Mellitus in conjunction with recommendations to consume a high protein diet in a 6 to 8 week withdrawal study. This study consisted of three phases: baseline, intervention, and follow-up. During the 2-week baseline and intervention phases participants consumed meals at regular times. Biochemical, anthropometric, and physical activity measurements were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose and fasting duration on a daily basis, in addition to completing a remote food photography diary three times within each study phase. Despite the short duration of the intervention phase, intermittent fasting led to significant decreases in weight, BMI, morning SMBG, and overall reductions in waist circumference, C-reactive protein, energy intake, carbohydrate intake, and fat intake. There were significant variations between participants in response to intermittent fasting in respect to changes in lipids and insulin sensitivity, which could not be explained by baseline biochemical or anthropometric measures, fasting duration, energy intake, or physical activity. Upon cessation of intermittent fasting, biochemical changes regressed towards baseline values during the follow-up period. Intermittent fasting was well tolerated by most participants, and no severe adverse events were noted. Morning nausea was the most common complaint, which abruptly ceased when medication timing was changed.
      Degree
      Master of Science (M.Sc.)
      Department
      Pharmacy and Nutrition
      Program
      Pharmacy
      Supervisor
      Arnason, Terra; Mansell, Kerry
      Committee
      Shoker, Ahmed; Davis, Karen; Arnold, Bart; Chizen, Donna
      Copyright Date
      September 2015
      URI
      http://hdl.handle.net/10388/ETD-2015-09-2226
      Subject
      Intermittent Fasting
      Type 2 Diabetes
      Type 2 Diabetes Mellitus
      Diabetes Mellitus Type 2
      Non Insulin Dependent Diabetes Mellitus
      NIDDM
      IF
      High Protein Diet
      Meal Frequency
      Self-Monitored Blood Glucose
      Fasting
      Fast
      Collections
      • Graduate Theses and Dissertations

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