RAGE-DEPENDENT SENSITIZATION OF THORACIC SENSORY NEURONS DURING INFLAMMATORY CONDITIONS
| dc.contributor.advisor | Campanucci, Veronica | |
| dc.contributor.advisor | Ianowski, Juan | |
| dc.contributor.committeeMember | Mulligan, Sean | |
| dc.contributor.committeeMember | Chlan-Fourney, Jennifer | |
| dc.contributor.committeeMember | Cayabyab, Francisco | |
| dc.creator | G Baskaran, Manoj Nair 1984- | |
| dc.date.accessioned | 2016-12-19T15:41:17Z | |
| dc.date.available | 2016-12-19T15:41:17Z | |
| dc.date.created | 2016-12 | |
| dc.date.issued | 2016-12-19 | |
| dc.date.submitted | December 2016 | |
| dc.date.updated | 2016-12-19T15:41:17Z | |
| dc.description.abstract | Various airway inflammatory diseases progress as a result of chronic inflammation, specifically neurogenic inflammation. One factor known to be involved in this is RAGE. This work has established RAGE as a key mediator in LPS-induced sensitization of afferent thoracic dorsal root ganglia neurons of the upper airway in mice. This was demonstrated from electrophysiological data showing the failure of LPS to potentiate capsaicin-evoked TRPV1 currents and increase action potential generation in RAGE KO relative to wild-type thoracic neurons. Mass spectrometry analysis for protein identification represents a step forward in biochemistry, allowing to obtain a global picture of the proteins expressed in a cell, including isoforms, post-translational modifications and downstream signalling pathways. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/10388/7630 | |
| dc.subject | RAGE, RAGE isoforms, RAGE KO, thoracic dorsal root ganglia, LPS, airway inflammatory disease, neurogenic inflammation, sensory neuron sensitization | |
| dc.title | RAGE-DEPENDENT SENSITIZATION OF THORACIC SENSORY NEURONS DURING INFLAMMATORY CONDITIONS | |
| dc.type | Thesis | |
| dc.type.material | text | |
| thesis.degree.department | Physiology | |
| thesis.degree.discipline | Physiology | |
| thesis.degree.grantor | University of Saskatchewan | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.Sc.) |