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Item Carbon Pricing: Factors that Influence Behavioural Intention for a Greener Future(2019) Skulski, Katherine; Zhang, David DiItem Operational Limitations and Regulations on Canadian Walk-In Clinics(2021-04) Milton, Bradley; Samarghandi, HamedThe Canadian healthcare system provides episodic, or walk-in clinics in each of it’s Provinces. These are funded by Canadian tax dollars which are allocated by Provincial government. This paper was written to identify and elaborate on how Walk-in Clinics are created, who can own and operate one, how said owners hire their physicians, and how the physicians are compensated. To identify the relevant information, I searched government and organizational websites, academic research and journal articles, and finally corresponded with contacts within each Province’s governing bodies to find relevant policy data and documents. Anything related to the key questions was synthesized into this research. There are no limitations to who can open a clinic or where, except in Prince Edward Island. Physicians can be hired through postings similar to other professions. Finally, Physicians are compensated through a Fee-for-Service method in Walk-in Clinics. Further explanation of these findings is discussed at length throughout this work, and limitations, recommendations, and important data is included.Item Are honey bees a suitable model for fetal alcohol spectrum disorders?(2022) Bevelander, Breanne; Simko, Elena; Polizel Camilli, Marcelo; Thebeau, Jenna; da Silva, Marina; Markova, Sofiia; Lester, Tessa; Obshta, Oleksii; Biganski, Sarah; Brown, Vanessa; Kozii, Ivanna; Masood, Fatima; Jose, Midhun; Moshynskyy, Igor; Raza, Fahim; Roulin, Melanie; Simko, Elemir; Wood, SarahFetal alcohol spectrum disorders (FASDs) are a continuum of disorders caused by prenatal exposure to ethanol. They affect an estimated 4% of Canadians. FASDs are associated with a host of complications including, but not limited to, cognitive difficulties, developmental delay, increased mortality, smaller birth weight, smaller brain size, as well as gross and fine motor issues. It has been previously established that fruit flies (Drosophila melanogaster) are a suitable invertebrate model for FASDs. Honey bees (Apis mellifera) share many similarities to Drosophila as a research model, but with the distinct advantage of highly social behaviour, similar to that of humans. In this project we exposed honey bees to incremental, sublethal concentrations of ethanol during larval development and monitored their survival, developmental rate, and weight at adult emergence. We found that larval honey bees exposed to ≥6% ethanol experienced significantly higher mortality, developmental delay, and lower body weight at emergence. Accordingly, these results, in combination with ongoing neurobehavioural analyses of adult bees exposed to ethanol as larvae, suggest that honey bees may be an ideal model for human FASDs.Item Identifying Protein-Protein Interactions of DDX41 by BioID(2022) Toliat Zavareh, Seyed Mohammad Mahdi; Charaya, Ananaya; Xiang, Jim; Wu, YuliangHelicases are known as enzymes that separate double-stranded(ds) nucleic acids to single-strand(ss) nucleic acids by hydrolysis ATP; and some of them also can anneal ss nucleic acids to ds nucleic acids in an ATP-independent manner. DEAD-box helicases are characterized by containing an Asp-Glu-Ala-Asp (DEAD) sequence in their motif II that is required for ATP binding and hydrolysis. DEAD-box helicase 41 (DDX41) is a member of DEAD-box helicases with multiple functions, including acting as a sensor for intracellular DNA in myeloid dendritic cells1 and for bacterial secondary messengers (c-di-GMP or c-di-AMP) to trigger type 1 interferon production2. Recently, the Dr. Wu’s lab discovered that DDX41 modulates the balance of dsDNA and ssDNA, in which regulates the activation of the cyclic GMP–AMP synthase (cGAS)3. Mutations in DDX41 are linked with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)4, two blood caners. The most recurring mutation in DDX41 that lead to AML or MDS is c.1574G>A (p.R525H). Despite concrete evidence suggests that DDX41 acts as a DNA sensor in innate immunity5,6; no innate immunity-related protein has been identified as a DDX41-binding partner. Therefore, we established a BioID system to identify DDX41-biniding proteins under virus infections.Item Does hive strength predispose honey bees to European foulbrood disease?(2022) Brown, Vanessa; Thebeau, Jenna; Masood, Fatima; Jose, Midhun; Obshta, Oleksii; da Silva, Marina; Markova, Sofiia; Bevelander, Breanne; Simko, Olena; Lester, Tessa; Biganski, Sarah; Raza, Fahim; Polizel Camilli, Marcelo; Moshynskyy, Igor; Guarna, Maria Marta; Gerbrandt, Eric; Wood, Sarah; Kozii, IvannaEuropean Foulbrood (EFB) is a bacterial disease of young honey bee larvae, caused by Melissococcus plutonius infection of the larval midgut. It occurs in times of nutritional stress when insufficient food is supplied to the larvae by the nursing bee population. EFB increases larval mortality, thereby limiting the colony’s growth, which can have consequences on the hive’s pollination services, honey production, and ability to reproduce. Recently, increased incidence of EFB has been observed across North America; however, the underlaying factors predisposing colonies to EFB remain largely unknown.Item Attitudes Towards Diet and Mental Health among the USask Community(2022) Cresswell, Heather; Lenz, Abigail; Thienes, Auburn; Hansen, KatelynneItem Exploring History with Augmented Reality: VR Simulations in Historical Heritage(2022) Ortiz Buitrago, Cesar DavidDevelop Virtual Environments to explore the History with new digital tools and engage the publics with the story of commodities and explain the supply chains between Canada and United Kingdon during late XIX and early XX Century from London Docks to Port of Quebec and Prairies in Saskatchewan.Item How Does the University of Saskatchewan Community Interact With Food Labels?(2022) Kusch, Thera; McLeod, Spencer; Monette, James; Szukaylo, KayleeItem Toll-Like Receptor 10 in Human Lungs(2022) Fowler, Brooke; Singh, Baljit; Aulakh, GurpreetThe biggest infectious disease outbreaks have been respiratory diseases, which are a leading cause to death and disability in humans. Though the use of antibiotics has helped greatly, challenges occur due to the evolution of anti-microbial resistance. Fortunately, the body has an innate immune system that is the primary response when an infection invades the lungs. Toll-like receptors are important for this primary response. They recognize pathogens and initiate a cascade of events to activate an inflammatory response. Toll-like receptor 10, also known as TLR10, has a unique anti-inflammatory function. This is different compared to the other TLRs, since they have pro-inflammatory properties. TLR10 is the latest TLR to be discovered, therefore little data can be found on its expression and very little is known about its function.Item Plant pathogen effects on Hemipteran Settling Behavior(2022) Irvine, Jeremy; Romero, Berenice; Prager, SeanPlants in agricultural systems are often subject to many harmful pathogens, including fungal and bacterial diseases, viruses, and mollicutes. Once a plant senses a stressor, many will begin to produce various secondary metabolites such as phytoalexins which can alter the plant’s physiological state. In previous work, it has been established that these compounds’ presence can affect the feeding behaviour of herbivorous species. Past studies have shown that plants infected with a pathogen can have decreased levels of amino acids and sugar compounds when compared to uninfected plants, which can consequently contribute to decreased insect attraction to infected plants. Aster Yellows Phytoplasma (AYP) is a mollicute that infects a very wide variety of hosts, many of which are important to the agricultural sector in Canada. Research into the pathosystem involving AYP, insect vectors, and the host plant is needed to understand to what degree infected plants might influence insect behaviour and disease dynamics. This study used healthy Canola plants (Brassica napus) along with plants infected with Aster Yellows Phytoplasma in no-choice and two-choice bioassays to evaluate the effects of pathogen infection has on vector settling behaviour, developmental time, rate of oviposition, and probing activity. This same process will be repeated with Cucumber Mosaic Virus and Turnip Mosaic Virus to determine if a viral infection will result in similar effects.Item SIR Infectious Disease Modelling with Vaccination(2022) Chen, Cindy; Cheviakov, AlexeiItem Using the lboxcox R package to fit a logistic Box-Cox model without using R(2022) Zbitniff, Mathew; Xing, Li; Li, LinaItem Magnetic Force Layouts for Cytoscape(2022) Shvets, Mykyta; MORADI, EHSAN; Mondal, DebajyotiItem The On-Going Conflict Between APOBEC3 Immune Factors and HIV-1 Vif(2022) Minhas, Tanvir; Gaba, Amit; Chelico, LindaItem Exploring cholesterol crystallization and ER stress in human liver cells(2022) Bairos, Jordan; Widenmaier, ScottItem INTEGRATING AND RUNNING COGE’S SYNMAP IN VIZSCIFLOW: A VISUALLY GUIDED SCIENTIFIC WORKFLOW MANAGEMENT FRAMEWORK(2022) Vu, Chi; Roy, Banani; Hossain, Mainul; Falamarzi, AliItem Classifying lentil testa (seedcoat) phenotypes using unsupervised learning(2022) Ewen, Amanda; Horovatin, Samuel; Najafian, Keyhan; Bett, Kirstin; Wright, Derek; Stavness, Ian; Jin, LinglingLentils have different seed coat colours and patterns. Accurate classification of lentils by testa patterns helps plant scientists understand the genetics of seed coats in lentils. Computers can be used for this analysisItem Caffeine Consumption Behaviours at the University of Saskatchewan(2022) Shaw, Breanna; Cresswell, Baylee; Rutten, OliviaItem Validation of Flow Measurement in a Negative Pressure Ventilator for Prototyping of a Novel Transbronchial Biopsy Tool(2022) Yang, Bonnie Y.; Tyan, Chung-Chun; Boire, James R.; Montgomery, JuliaItem Mindful Eating in the University of Saskatchewan Community(2022) Ha, Esther; Phillips, Maya; Berg, Gabby; Novakowski, Sarah