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Item Are honey bees a suitable model for fetal alcohol spectrum disorders?(2022) Bevelander, Breanne; Simko, Elena; Polizel Camilli, Marcelo; Thebeau, Jenna; da Silva, Marina; Markova, Sofiia; Lester, Tessa; Obshta, Oleksii; Biganski, Sarah; Brown, Vanessa; Kozii, Ivanna; Masood, Fatima; Jose, Midhun; Moshynskyy, Igor; Raza, Fahim; Roulin, Melanie; Simko, Elemir; Wood, SarahFetal alcohol spectrum disorders (FASDs) are a continuum of disorders caused by prenatal exposure to ethanol. They affect an estimated 4% of Canadians. FASDs are associated with a host of complications including, but not limited to, cognitive difficulties, developmental delay, increased mortality, smaller birth weight, smaller brain size, as well as gross and fine motor issues. It has been previously established that fruit flies (Drosophila melanogaster) are a suitable invertebrate model for FASDs. Honey bees (Apis mellifera) share many similarities to Drosophila as a research model, but with the distinct advantage of highly social behaviour, similar to that of humans. In this project we exposed honey bees to incremental, sublethal concentrations of ethanol during larval development and monitored their survival, developmental rate, and weight at adult emergence. We found that larval honey bees exposed to ≥6% ethanol experienced significantly higher mortality, developmental delay, and lower body weight at emergence. Accordingly, these results, in combination with ongoing neurobehavioural analyses of adult bees exposed to ethanol as larvae, suggest that honey bees may be an ideal model for human FASDs.Item Attitudes and Practices Towards Eating with Others Among the University of Saskatchewan Community(2023) Meikle, Carlie; Oakenfold, Caitlyn; Stadnyk, Carolyn; Wilson, KaileeItem Attitudes Towards Diet and Mental Health among the USask Community(2022) Cresswell, Heather; Lenz, Abigail; Thienes, Auburn; Hansen, KatelynneItem Caffeine Consumption Behaviours at the University of Saskatchewan(2022) Shaw, Breanna; Cresswell, Baylee; Rutten, OliviaItem Carbon Pricing: Factors that Influence Behavioural Intention for a Greener Future(2019) Skulski, Katherine; Zhang, David DiItem Classifying lentil testa (seedcoat) phenotypes using unsupervised learning(2022) Ewen, Amanda; Horovatin, Samuel; Najafian, Keyhan; Bett, Kirstin; Wright, Derek; Stavness, Ian; Jin, LinglingLentils have different seed coat colours and patterns. Accurate classification of lentils by testa patterns helps plant scientists understand the genetics of seed coats in lentils. Computers can be used for this analysisItem Consumption of Cow's Milk vs. Plant-Based Beverages at USask (2023) Manlapaz, Jose Luis; Mitzel, Kylie; Poppleton, John; Tameling, JadeItem DNA Origami Nanotechnology(2023) Guarin, Angie; Mohammadi, Ozra; Stevens, Amy L.Item Does hive strength predispose honey bees to European foulbrood disease?(2022) Brown, Vanessa; Thebeau, Jenna; Masood, Fatima; Jose, Midhun; Obshta, Oleksii; da Silva, Marina; Markova, Sofiia; Bevelander, Breanne; Simko, Olena; Lester, Tessa; Biganski, Sarah; Raza, Fahim; Polizel Camilli, Marcelo; Moshynskyy, Igor; Guarna, Maria Marta; Gerbrandt, Eric; Wood, Sarah; Kozii, IvannaEuropean Foulbrood (EFB) is a bacterial disease of young honey bee larvae, caused by Melissococcus plutonius infection of the larval midgut. It occurs in times of nutritional stress when insufficient food is supplied to the larvae by the nursing bee population. EFB increases larval mortality, thereby limiting the colony’s growth, which can have consequences on the hive’s pollination services, honey production, and ability to reproduce. Recently, increased incidence of EFB has been observed across North America; however, the underlaying factors predisposing colonies to EFB remain largely unknown.Item Examining the Effect of Inflammation on HDL-Cholesterol Uptake by the Liver(2022) Hydomako, Aidan; Trites, Mike; Widenmaier, ScottItem Exploring cholesterol crystallization and ER stress in human liver cells(2022) Bairos, Jordan; Widenmaier, ScottItem Exploring History with Augmented Reality: VR Simulations in Historical Heritage(2022) Ortiz Buitrago, Cesar DavidDevelop Virtual Environments to explore the History with new digital tools and engage the publics with the story of commodities and explain the supply chains between Canada and United Kingdon during late XIX and early XX Century from London Docks to Port of Quebec and Prairies in Saskatchewan.Item How Does the University of Saskatchewan Community Interact With Food Labels?(2022) Kusch, Thera; McLeod, Spencer; Monette, James; Szukaylo, KayleeItem How Have Increased Grocery Prices Affected Food Purchasing Behaviours?(2023) Ackerman, Brooke; Foster, Breanna; Mansell, Erin; Wuchner, PaigeItem Identifying new protocol methods in polyploidy research with Cannabis sativa L(2023) Skuce, William; Sharbel, Tim; Bors, RobertThe development and critique of an improved experiment and protocol analysis is critical in terms of this research experiment. With little published research in the development of polyploid cannabis, it was crucial that steps were taken to test and report the methods and protocols provided thus far. The development and discovery that Pisum sativum L. impeded the ploidy analysis of Cannabis sativa L. in flow cytometry when used as an internal standard was recognized. In turn, these findings only reinforced the need to find and test better suited endogenous controls for Cannabis sativa L. samples within flow cytometry analysis. The works of producing a more suited protocol for Cannabis sativa L. flow cytometry we can better understand the effects of possible secondary metabolites between the plants within flow cytometry as well as help pave the way for future Cannabis sativa L. ploidy research.Item Identifying Protein-Protein Interactions of DDX41 by BioID(2022) Toliat Zavareh, Seyed Mohammad Mahdi; Charaya, Ananaya; Xiang, Jim; Wu, YuliangHelicases are known as enzymes that separate double-stranded(ds) nucleic acids to single-strand(ss) nucleic acids by hydrolysis ATP; and some of them also can anneal ss nucleic acids to ds nucleic acids in an ATP-independent manner. DEAD-box helicases are characterized by containing an Asp-Glu-Ala-Asp (DEAD) sequence in their motif II that is required for ATP binding and hydrolysis. DEAD-box helicase 41 (DDX41) is a member of DEAD-box helicases with multiple functions, including acting as a sensor for intracellular DNA in myeloid dendritic cells1 and for bacterial secondary messengers (c-di-GMP or c-di-AMP) to trigger type 1 interferon production2. Recently, the Dr. Wu’s lab discovered that DDX41 modulates the balance of dsDNA and ssDNA, in which regulates the activation of the cyclic GMP–AMP synthase (cGAS)3. Mutations in DDX41 are linked with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)4, two blood caners. The most recurring mutation in DDX41 that lead to AML or MDS is c.1574G>A (p.R525H). Despite concrete evidence suggests that DDX41 acts as a DNA sensor in innate immunity5,6; no innate immunity-related protein has been identified as a DDX41-binding partner. Therefore, we established a BioID system to identify DDX41-biniding proteins under virus infections.Item INTEGRATING AND RUNNING COGE’S SYNMAP IN VIZSCIFLOW: A VISUALLY GUIDED SCIENTIFIC WORKFLOW MANAGEMENT FRAMEWORK(2022) Vu, Chi; Roy, Banani; Hossain, Mainul; Falamarzi, AliItem Lattice Models of RNA-DNA R-loop Complexes(2023) Numedahl, Olivia; Schmirler, Matthew; Ferrari, Margherita Maria; Soteros, ChrisTwo models are combined to explore the formation and stability of DNA-RNA structures called R-loops. The first is a formal grammar model (FGM) developed by Ferrari and coworkers. The second is a simplified lattice model developed for studying R-loop formation and geometry by Soteros and coworkers for a PIMS VXML project. We combine these into one model and explore the model both theoretically and via computer simulation using Markov chains. The general goals are to explore the probability of R-loop formation and geometric properties of the R-loops.Item Magnetic Force Layouts for Cytoscape(2022) Shvets, Mykyta; MORADI, EHSAN; Mondal, DebajyotiItem Mindful Eating in the University of Saskatchewan Community(2022) Ha, Esther; Phillips, Maya; Berg, Gabby; Novakowski, Sarah